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Solid tumors harboring BRCA1 or BRCA2 mutations have been shown to respond to PARP inhibitors. In this case report, we describe an 82-year-old male with poorly differentiated prostate cancer with metastases to the lung, liver, abdomen, and bowel.
Molecular testing demonstrated alterations in BRCA2, ERG, and TP53.
Based on this result, he was enrolled in a therapeutic trial and received carboplatin, gemcitabine, and veliparib, to which he had a partial response.
He continued to respond while on veliparib maintenance alone, and after 38 cycles he had a sustained complete response.
PMID: 28482875Delphi Study to Determine Rehabilitation Research Priorities for Older Adults With Cancer. Lyons KD, Li HH, Mader EM, Stewart TM, Morley CP, Formica MK, Perrapato SD, Seigne JD, Hyams ES, Irwin BH, Mosher T, Hegel MTAm J Mens Health. Dionne-Odom JN, Azuero A, Lyons KD, Hull JG, Prescott AT, Tosteson T, Frost J, Dragnev KH, Bakitas MAJ Pain Symptom Manage.
In The Biology and Therapeutic Application of Mesenchymal Cells (ed K. PMID:27526954Lindstad T, Qu S, Sikkeland J, Jin Y, Kristian A, Mlandsmo GM, Collas P, Saatcioglu F. H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in h ESC-Derived Hepatocytes In Vitro..
Early molecular events during in vitro chondrogenesis. PMID:27517316Vanhove J, Pistoni M, Welters M, Eggermont K, Vanslembrouck V, Helsen N, Boon R, Najimi M, Sokal E, Collas P, Voncken JW, Verfaillie CM.
tony.balko[at]Tony Balko is an artist and educator from Smithton, Pennsylvania, USA.
He is the proud owner of a doctor's note allowing him to wear sweatpants to work.